Search results for "nano-into-micro strategy"

showing 1 items of 1 documents

Mucus and Cell-Penetrating Nanoparticles Embedded in Nano-into-Micro Formulations for Pulmonary Delivery of Ivacaftor in Patients with Cystic Fibrosis

2017

Here, mucus-penetrating nanoparticles (NPs) for pulmonary administration of ivacaftor in patients with cystic fibrosis (CF) were produced with the dual aim of enhancing ivacaftor delivery to the airway epithelial cells, by rapid diffusion through the mucus barrier, and at the same time, promoting ivacaftor lung cellular uptake. Pegylated and Tat-decorated fluorescent nanoparticles (FNPs) were produced by nanoprecipitation, starting from two synthetic copolymers, and showed nanometric sizes (∼70 nm), a slightly negative ζ potential, and high cytocompatibility toward human bronchial epithelium cells. After having showed the significant presence of poly(ethylene glycol) chains and Tat protein …

Materials scienceCystic FibrosisNanoparticle02 engineering and technologyQuinolones010402 general chemistryAminophenols01 natural sciencesCystic fibrosisIvacaftorchemistry.chemical_compoundmedicineHumansGeneral Materials ScienceMicroparticleDrug CarriersLungαβ-poly-(N-2-hydroxyethyl)-dl-aspartamide (PHEA)ivacaftor (VX-770)mucus-penetrating nanoparticlerespiratory system021001 nanoscience & nanotechnologymedicine.diseaseMucus0104 chemical sciencesMucusnano-into-micro strategymedicine.anatomical_structurechemistrycell penetrating peptideCell-penetrating peptideBiophysicsNanoparticlescystic fibrosis artificial mucus (CF-AM)0210 nano-technologyEthylene glycolmedicine.drug
researchProduct